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KMID : 0376219820190020163
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Chonnam Medical Journal
1982 Volume.19 No. 2 p.163 ~ p.169
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Changes in antibiotic susceptibility pattern among colonial variants of Pseudomonas aeruginosa
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Abstract
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Colonial variants, S-, SR-, and R-forms were obtained from old cultures of Pseudomonas aeruginosa (Ps.).
In order to investigate what effect the colonial dissociation brings about on the antibiotic susceptibility pattern of the colony, some antibiotics, which have recently been most frequently used in treating Ps. infections, i.e., carbenicillin (CB), sulbenicillin (SB), gentamicin (GM), and tobramycin (TM), were used singly or in combination against each colony and their minimal inhibition concentrations (MIC) were compared each other; isobolograms and fractional inhibition concentration index (FICI) were also employed for the detection of synergism when combined antibiotics were used.
The results obtained were as follows.
When each drug was used alone, as colonial form dissociation advanced the resistance to aminoglycosides decreased while increasing to penicillins. This decrement was particularly distinguished in the resistance of Ps.53 to GM and TM.
Synergic effects between CB and GM against each colonial form were various and unpredictable; S-form of Ps. 53 was inhibited synergically while SRor R-forms reacted only additionally. In Ps-56, on the other hand, R-form showed a considerably low value of FICI, indicating an effective inhibition by the combined drugs.
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